The San Francisco 49ers are likely to be without running back Isaac Guerendo when they face the Miami Dolphins on Sunday. According to ESPN’s Adam Schefter, Guerendo is dealing with a hamstring injury that will probably keep him out of the game.
Guerendo’s injury is the latest blow to the 49ers’ running back corps, which has been decimated by injuries this season. Christian McCaffrey, Jordan Mason, and Elijah Mitchell have all suffered season-ending injuries, leaving Guerendo as the top running back on the depth chart.
Guerendo’s hamstring injury occurred during last week’s game against the Los Angeles Rams. He had been listed as questionable for that game due to a foot injury, but was able to play. However, he did not participate in Wednesday’s practice, which suggests that the hamstring injury is a significant concern.
The 49ers have a few other running backs on their roster who could potentially replace Guerendo. Patrick Taylor Jr. and Israel Abanikanda are the other running backs on the 53-man roster, and Taylor is expected to get the first shot at replacing Guerendo.
The 49ers also have running back Ke’Shawn Vaughn on their practice squad, and he has been elevated to the active roster for the past two games. Vaughn could potentially see some playing time on Sunday if Guerendo is unable to play.
Guerendo has been a bright spot for the 49ers this season, rushing for 381 yards and four touchdowns. His absence will likely be felt on Sunday, especially if the 49ers are unable to find a suitable replacement.
The 49ers are also likely to be without left tackle Trent Williams on Sunday. Williams has missed the past four games with an ankle injury, and coach Kyle Shanahan said on Wednesday that it’s “getting closer” to the point where Williams will be sidelined for the rest of the season.
The 49ers are still mathematically alive for a playoff spot, but they will likely need to win all three of their remaining games and get some help from other teams in order to qualify.